ABSTRACT Introduction Nursing is one of the professions with high Burnout levels, taking into account that it is subjected to constant situations of emotional exhaustion and stress. It is essential to invest in Burnout prevention strategies for Nurses, since high levels of stress jeopardize the quality and effectiveness of their work, and consequently have a strong impact on patients' health and in their own quality of life. Occupational Health plays an important role in the prevention, identification and control of Burnout levels in Nurses. Objectives and Methodology To this end, we conducted a review using the B-on and SciELO databases, including articles published between january 2015 and march 2022, in portuguese and english, which addressed Burnout prevention strategies among Nurses. The following descriptors/terms were used: Burnout, Prevention Strategies and Nurses, which were combined with the boolean operator AND. Seven articles were selected for further analysis of evidence. Results The prevention of Burnout syndrome in Nurses requires the adoption of strategies, both at the individual and organizational levels. Nurses should develop the ability to self-monitor stress and self-recognize the signs and symptoms of Burnout, with a view to promoting their mental health and well-being. The organization has the possibility to create the necessary conditions for a healthier and less stress-promoting workplace. Strategies such as resilience training, frequent yoga practice, promotion of self-care, engagement and encouragement of mental health promotion were identified, and it was found that Nursing teams with mental health empowered members are able to perform higher quality and more effective functions. Conclusions It is crucial to study this topic more, since with the appropriate strategies focused on the prevention of Burnout syndrome, there is a noticeable decrease in stress levels among Nursing team members, and consequently an improvement in the quality of care provided.

RESUMO Introdução A Enfermagem é considerada como uma das profissões com níveis de Burnout elevados, tendo em conta que se encontra sujeita a constantes situações de exaustão emocional e stress. É fulcral apostar em estratégias de prevenção, pois elevados níveis de stress colocam em causa a qualidade e a eficácia do trabalho prestado, tendo consequentemente um forte impacto na saúde dos doentes e na sua própria qualidade de vida. A Saúde Ocupacional desempenha um papel importante na prevenção, na identificação e no controlo dos níveis de Burnout nos Enfermeiros. Objetivos e Metodologia Com este trabalho pretende-se identificar as estratégias existentes na prevenção do Burnout nos Enfermeiros, para isso, realizou-se uma revisão da literatura, com pesquisa em bases de dados acedidas através da plataforma B-on e da base de dados SciELO, incluindo artigos publicados entre janeiro de 2015 e março de 2022, em língua portuguesa e inglesa e que abordassem as estratégias na prevenção do Burnout nos Enfermeiros. Utilizaram-se os descritores Mesh: Burnout, Prevention Strategies e Nurses, os quais foram conjugados com o operador booleano AND. Foram selecionados sete artigos para posterior análise. Resultados A prevenção da síndrome de Burnout nos Enfermeiros passa pela aposta na adoção de estratégias, tanto a nível individual, como organizacional. O Enfermeiro deve desenvolver a capacidade de autocontrolo do stress e de autorreconhecimento dos sinais e sintomas de Burnout, com vista a promover a sua saúde mental e o seu bem-estar. A organização tem a possibilidade de criar as condições necessárias para um local de trabalho mais saudável e menos promotor de stress. Foram identificadas estratégias como o treino de resiliência, prática de yoga, promoção do autocuidado, comprometimento organizacional e incentivo à promoção da saúde mental, verificando-se que equipas de Enfermagem com elementos mais capacitados em saúde mental conseguem desempenhar funções de maior qualidade e eficácia. Conclusões É fulcral o estudo crescente desta temática, uma vez que com estratégias adequadas e focadas na prevenção da síndrome de Burnout, poder-se-á diminuir os níveis de stress nos elementos das equipas de Enfermagem e consequentemente uma melhoria da qualidade dos cuidados prestados.

RESUMO Neste trabalho, uma análise comparativa entre as wavelets Gaussianas e Golden é apresentada. Tais wavelets são geradas pela derivada de uma função basica específica. Nesse caso, a ordem da derivada também indica o número de momentos nulos da wavelet. Embora essas wavelets tenham formas de onda muito semelhantes, elas possuem várias características distintas nos domínios do tempo e da frequência. Essas distinções são exploradas aqui no espaço de escalas. A fim de comparar os resultados das wavelets para um sinal real, essas wavelets são usadas na decomposição de um sinal inserido no contexto do sistemas de monitoramento de integridade estrutural.

ABSTRACT In this work, a comparative analysis between Gaussian and Golden wavelets is presented. These wavelets are generated by the derivative of specific base functions. In this case, the order of the derivative also indicates the number of vanishing moments of the wavelet. Although these wavelets have a similar waveform, they have several distinct characteristics in time and frequency domains. These distinctions are explored here in the scale space. In order to compare the results provided by these wavelets for a real signal, they are used in the decomposition of a signal inserted in the context of structural health monitoring.

Resumo A eficiência da irradiação sonora em estrutura possui relação direta com seu movimento vibratório. Absorvedores dinâmicos de vibrações (ADVs) são uma opção viável de baixo custo para redução de vibrações em estruturas de forma passiva. São sistemas secundários fixados ao sistema primário (estrutura) com propósito de reduzir as vibrações do sistema primário. Neste trabalho foi utilizado um procedimento de Análise Modal Experimental (AME) para obter experimentalmente as frequências naturais e a localização dos pontos adequados para fixação dos ADVs em uma viga de concreto. Posteriormente, foram projetados e construídos ADVs para redução de vibração em uma banda de frequência onde a resposta do sistema auditivo humano é mais sensível. A melhor configuração de projeto para os ADVs foi avaliada quanto à sensibilidade dos mesmos com relação à alteração do fator de perda do material viscoelástico utilizado. Obteve-se redução superior a 36% ao longo da banda de frequência considerada, e superior a 70 % na região da frequência de ressonância na qual os ADVs estavam sintonizados.

Abstract The efficiency of sound irradiance in structure has direct relation with its vibratory movement. Dynamic vibration absorbers (DVAs) are a low cost viable option for reducing vibrations in passive structures. Secondary systems attached to the primary system (structure) in order to reduce vibration. In this work it was used an experimental modal analysis procedure (EMA) for vibratory responses through impulsive excitations to determine the natural frequencies and the location of points suitable for attachment of DVAs in a concrete beam. Later it was designed and built DVAs to reduce vibration in a frequency band where the response of the human auditory system is more sensitive. The best project configuration for DVAs was evaluated for sensitivity thereof with respect to the change of the loss factor of the viscoelastic material used. Obtained reduction of more than 36% over the considered frequency band and over 70% in the region of the resonance frequency in which the DVAs were tuned.

ABSTRACT Objective We investigated the postprandial response of lipid markers to a high-fat meal (HFM) with two different beverages in apparently healthy normal-weight and overweight/obese women. Subjects and methods This crossover, randomized study enrolled 36 women, of whom 21 had normal weight (body mass index [BMI] 22 ± 1.8 kg/m2) and 15 had overweight/obesity (BMI 31 ± 3.7 kg/m2). In two different test days, the participants ingested a HFM (37% of energy as saturated fat) with 500 mL of water (HFM-W) or 500 mL of orange juice (HFM-OJ). Blood samples were collected at baseline (12-hour fasting), and at 2, 3, and 5 hours postprandial. The analysis included fasting and postprandial total cholesterol, HDL-c, LDL-c, triglycerides (TG), uric acid, and complement C3. Brazilian Clinical Trials Registry (ReBEC); Primary Identification Number: RBR-2h3wjn (www.ensaiosclinicos.gov.br). Results TG levels increased at 3 hours with HFM-OJ in normal-weight women (p = 0.01) and returned to normal levels at 5h. TG increased at 3 hours with HFM-W (p = 0.01) and HFM-OJ (p = 0.02), and remained high at 5 hours (p = 0.03) in overweight/obese women. Complement C3 remained unchanged, but showed different responses between meals (p = 0.01 for positive incremental area under the curve [piAUC] HFM-OJ vs. HFM-W, respectively). Conclusions In apparently healthy overweight/obese women compared with normal-weight ones, the concomitant intake of orange juice with a HFM prolonged postprandial lipemia but had no effect on postprandial complement C3 concentrations.

Abstract The synthesis and characterization of a mesoporous molecular sieve (MCM-41) was studied due to its high surface area and large pore volume and to target potential applications in adsorption and catalysis. Rare earth elements have special chemical properties and are efficient promoters for supports. In this study, a mesoporous molecular sieve that incorporates the transition metal cerium (Ce-MCM-41) was synthesized using the hydrothermal method with the goal of improving the structural properties for adsorption. The molar composition of the obtained gel was 1CTMABr: 4SiO2: 1Na2O: 0.2Ce2O3: 200H2O. The pure mesoporous molecular sieve MCM-41 was also synthesized using the same method. The materials were characterized by the following techniques: XRD, BET/BJH, SEM/EDS, TG and FT-IR. A preliminary test to evaluate the materials as adsorbents to remove naphthenic acids present in jet fuel was performed. The results of the characterization showed that the incorporation of the metal cerium did not affect the MCM-41 structure and that mesporous materials were formed. Ce-MCM-41 exhibited good thermal stability, high specific surface area and large pore volume, which are characteristics of a good adsorbent. From the preliminary test, the adsorptive capacity increased by 60% with the incorporation of cerium in the MCM-41 structure.

Este artigo apresenta uma melhoria para a formulação de Sherlock e Monro para a parametrização wavelet para a obtenção das restrições que garantem três momentos nulos. A fim de testar a formulação apresentada, um exemplo de detecção de transitórios em sinais é apresentada.

This article presents an improvement to the formulation of Sherlock and Monro for the wavelet parameterization for the obtainment of the restrictions which ensure three vanishing moments. In order to test the formulation presented, a transient signal detection is presented.

Insufficient serum vitamin D is associated with various disorders with high prevalence at global and regional levels. In our country, there are not published studies related to this matter. In this descriptive, observational study with analytical component, the levels of vitamin D and the prevalence of its insufficiency were determined in young people and also the possible associations with known risk factors like sun exposure, sunscreen use and lack of consumption of vitamin D-enriched foods were analyzed. One hundred medical students and members of the staff of the Hospital de Clinicas of the National University of Asuncion, Paraguay were included. Participants were aged 20 to 30 years and 69% of them were women. The mean concentration of vitamin D was 17.6 ± 6.25 ng/dl (range: 4-38); 53% of the participants had insufficient levels of vitamin D (10-20 ng/dL) and 11% had vitamin D deficiency (less than 10 ng/dL). Although the individuals who reported consumption of dairy products and non-use of sunscreen had higher levels of vitamin D, the difference was not statistically significant. A high frequency of vitamin D insufficiency was found in this population in agreement with similar studies carried out at worldwide and regional levels. Vitamin D supplementation is recommended in the population to prevent disorders associated with the deficiency.

La insuficiencia de vitamina D sérica se asocia a diversos trastornos, con alta prevalencia a nivel regional y mundial. En nuestro país no existen estudios publicados al respecto. En este estudio observacional, descriptivo, con componente analítico se determinaron niveles de vitamina D y prevalencia de su insuficiencia en jóvenes y se indagó posibles asociaciones con factores de riesgo conocidos como la falta de exposición solar, uso de protectores solares, y falta de consumo de alimentos ricos en vitamina D. Fueron incluidos 100 estudiantes y funcionarios del Hospital de Clínicas de la Universidad Nacional de Asunción, a quienes se les tomó una muestra de sangre y llenaron un cuestionario. Los niveles de vitamina D fueron determinados por el método ECLIA (inmunoensayo de electroquimioluminiscencia). Las edades estaban entre 20 y 30 años, el 69% era del sexo femenino. La concentración media ± desvío estándar de vitamina D fue de 17,6 ± 6,25 ng/dl (rango: 4-38). El 53% de los participantes presentaba insuficiencia (10 a 20 ng/dL) y 11% deficiencia (<10 ng/dL) de vitamina D. Aunque los participantes que reportaron consumir lácteos y no utilizar protectores solares tuvieron mayores niveles de vitamina D, la diferencia no fue estadísticamente significativa. Se encontró una frecuencia elevada de insuficiencia de vitamina D en esta población, en concordancia con los hallazgos de estudios similares a nivel mundial y regional. Se recomienda la suplementación con vitamina D en la población de manera a prevenir los trastornos asociados con la deficiencia de esta vitamina.

This article describes the case of an infant under 2 months old, who at 15 days of age presented stridor and respiratory distress, a chest X-ray was performed which reported the presence of a hyperinflation of the right lung field. A fiberoptic bronchoscopy (FBO) was performed which resulted normal and a ventilation/perfusion gammagraph showed a right lung hypoplasia. The infant was treated with additional oxygen and respiratory therapy without clinical. In order to obtain a pre-surgical vascular map, a multislice CT angiography and virtual bronchoscopy were performed, documenting a right bronchial stenosis produced by a fold of the bronchial wall and with valve effect which produced a secondary hyperinsufflation of the right lung. These findings were confirmed in corrective surgery.

En este artículo se reporta el caso de un lactante menor de 2 meses de edad que a los 15 días de nacido presentó estridor y dificultad respiratoria, por lo que consultó a una clínica de primer nivel en donde se le realizó radiografía de tórax, en la cual se documentó la presencia de una hiperinfiación del campo pulmonar derecho. Se realizó una fibrobroncoscopía óptica (FBO) que fue reportada como normal y una gammagrafía de ventilación/perfusión que reportó una hipoplasia pulmonar derecha. Fue manejado con oxígeno suplementario y terapias respiratorias sin mejoría clínica, motivo por el cual fue trasladado a nuestra institución para manejo especializado. Con el fin de obtener un mapa vascular pre quirúrgico, se realizó una angiografía pulmonar por tomografía (Figura 2) reconstrucciones con mínima intensidad de proyección (Figura 3) y broncoscopía virtual (BV) multicorte (Figuras 4 y 5) documentándose una estenosis del bronquio fuente derecho, producida por un repliegue de la pared bronquial y con efecto de válvula que producía una hiperinsufiación secundaria del pulmón derecho. Estos hallazgos fueron confirmados en la cirugía correctiva.

A partir da 2-cloro-3-formilpiridina, sintetizou-se uma série de compostos derivados da 1H-pirazolo[3,4-b]piridina de modo a obter os correspondentes 1-hidroxibisfosfonatos, uma classe de compostos com potencial interesse biológico. Os dados espectroscópicos foram utilizados na caracterização de todos os compostos e na identificação dos regioisômeros N-1 e N-2, e dos derivados mono- e bisfosfonatos. Estudos de difratometria de raios X do composto 7a confirmaram a estrutura proposta.

A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono-and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.

The influence of vitamin D deficiency in postmenopausal women is a major issue for the implications in the phospho-calcium metabolism and their possible association in the development of other pathologies. This study aimed to determine the prevalence of hypovitaminosis D in a population of postmenopausal women and its association with changes in the phospho-calcium metabolism and the development of osteoporosis. We included 67 postmenopausal women from a rheumatology outpatient clinic. We considered the following clinical variables (ie age, weight), laboratory (ie concentrations of calcium, phosphorus and PTH) and the presence or absence of osteopenia or osteoporosis. The value of the mean age of patients was 66 ± 11.29 years and we observed vitamin D concentrations below 30 ng/ml in 50 (74.6%) patients. Also, we found osteopenia or osteoporosis in an important part of our patients but did not find a significant correlation between the concentrations of vitamin D and calcium and phosphorus concentrations. We found a negative correlation in relation to the concentrations of PTH (P = 0.049). Patients with osteoporosis or osteopenia frequently present hypovitaminosis D and because of this, there is a need for early detection and treatment to prevent the serious complications that could accompany the loss of bone density in these patients.

La influencia de la hipovitaminosis D en la mujer post-menopáusica constituye un tema de gran importancia por las implicancias en el metabolismo fosfo-cálcico y su posible asociación en el desarrollo de otros tipos de patologías. Es por eso que el presente estudio tiene por objetivo conocer la prevalencia de la hipovitaminosis D en una población de mujeres post-menopáusicas y su asociación con los cambios en el metabolismo fosfocálcico y con el desarrollo de la osteoporosis. Se incluyó 67 mujeres post-menopáusicas procedentes de una consulta ambulatoria de reumatología. Se consideraron las siguientes variables clínicas (i.e. edad, peso), laboratorio (i.e. concentraciones de calcio, fosforo y PTH) y la presencia o ausencia de osteopenia u osteoporosis. El valor de la media de la edad de las pacientes fue de 66 ± 11,29 años y las concentraciones de vitamina D inferior a 30 ng/ml se observó en 50 (74,6%) pacientes. La osteopenia u osteoporosis se observó en una parte importante de nuestros pacientes. No se observó una correlación significativa entre las concentraciones de vitamina D y las concentraciones de calcio y fósforo. Se observóuna correlación negativa en relación a las concentraciones de PTH (P= 0,049). Las pacientes con osteoporosis u osteopenia presentan con frecuencia hipovitaminosis D. Es por eso que existe la necesidad de realizar una detección y tratamiento temprano a fin de evitar las graves complicaciones que podrían acompañar a la pérdida de densidad ósea en este grupo de pacientes.

El conocimiento de la afidofauna local y los parasitoides asociados a estas especies, constituyen el elemento básico para la implementación del control biológico. Con este fin, se desarrollaron en sistemas urbanos, inspecciones quincenales en el periodo de noviembre a abril, de los años 2008, 2009 y 2010, en diferentes hortalizas y otras plantas acompañantes, de las provincias Mayabeque y La Habana. De cada cultivo se tomaron muestras con presencia de diferentes fases del desarrollo de áfidos, las que fueron revisadas diariamente hasta la emergencia de los parasitoides, éstos, al igual que los áfidos, fueron montados en portaobjetos e identificados, según las claves correspondientes. Los áfidos encontrados fueron: Lipaphis erysimi, Myzus persicae, Aphis gossypii, A. craccivora, A. spiraecola, A. helianthi, A. fabae, A. nerii, Aphis sp., Rhopalosiphum maidis y Brevicoryne brassicae en 13 hortalizas y 11 plantas acompañantes; los parasitoides asociados fueron: Diaeretiella rapae, Lysiphlebus testaceipes, Aphelinus abdominalis y los hiperparásitos Pachyneuron sp. y Syrphophagus aphidivorus. Se hallaron 16 relaciones tritróficas en hortalizas y seis en plantas acompañantes.

Knowledge on the local aphid fauna and of their associated parasitoids is a key element for the implementation of biological control. With this objective, surveys in urban areas were carried out every two weeks on several vegetables and other associated plants from November to Abril, in Mayabeque and La Havana provinces from 2008 to 2010. Samples taken from each crop were observed daily until parasitoid emergency. Both aphids and parasitoids were slide-mounted for identification. Aphid species found were: Lipaphis erysimi, Myzus persicae, Aphis gossypii, A. craccivora, A. spiraecola, A. helianthi, A. fabae, A. nerii, Aphis sp., Rhopalosiphum maidis and Brevicoryne brassicae; and the parasitoids species were: Diaeretiella rapae, Lysiphlebus testaceipes, Aphelinus abdominalis. The hiperparasitoids Pachyneuron sp. and Syrphophagus aphidivorus were foundtoo. Sixteen tritrophic relations were found in vegetables and six in alternating hosts.

Background: Raynaud's phenomenon, a vascular disorder that is common in the general population, consists of paroxysmal onset distal vasospasm in small cutaneous arteries and arterioles of extremities, usually with little systemic impact. There are anatomical and physiological bases to produce a selective sympathetic block ad using neurolytic agents in the thoracic ganglia T2 and T3 considered synaptic stations that are distributed in the upper limb. Objective: The objective of this work was to determine the efficacy of neurolytic block of the third dorsal ganglion due to Raynaud's syndrome in a series of cases. Material and methods: A review of records of eight cases with Raynaud's phenomenon that presented multifactorial origin were conducted on Clinic of the Pain located in the Unidad Médica de Alta Especialidad, Monterrey Nuevo León, México. Cases: Eight patients from 41 to 72 years old were medically treated for Raynaud's phenomenon using sympathicolysis dorsal third node. Conclusions: Raynaud's phenomenon with a prevalence ranging from 1 to 25% has an increased sympathetic activity. The ischemic pain that is determined by total or partial failure in the oxygen transport to tissues was reduced in these patients by performing a selective sympathicolysis in the thoracic ganglia T2 and T3 considered synaptic stations that are distributed in the upper limb. It was demonstrated in this study that this treatment is selective with less adverse effects to the patients.

Introducción: El fenómeno de Raynaud es un trastorno vascular, frecuente en la población general, que consiste en la aparición paroxística de espasmo vascular distal, en pequeñas arterias y arteriolas cutáneas de las extremidades, con escasa repercusión sistémica. Existen bases anatómicas y fisiológicas para producir un bloqueo simpático selectivo utilizando agentes neurolíticos en los ganglios torácicos T2 y T3, considerados estaciones sinápticas que se distribuyen en el miembro superior. Objetivo: Determinar la eficacia del bloqueo neurolítico del tercer ganglio dorsal en el síndrome de Raynaud de una serie de casos. Material y métodos: Se realizó la revisión de expedientes de una serie de ocho casos con fenómeno de Raynaud de causa multifactorial, en la Clínica del Dolor de la Unidad Médica de Alta Especialidad Monterrey; Nuevo León, México. Casos: Ocho casos de 41 a 72 años de edad con fenómeno de Raynaud, tratados médicamente, a los cuales se les realizaron simpaticolisis del tercer ganglio dorsal. Conclusiones: El fenómeno de Raynaud tiene una prevalencia que va del 1 al 25%, en este hay una actividad simpática aumentada por lo que al realizar una simpaticolisis selectiva se logra mejorar el dolor isquémico, el cual está determinado por la insuficiencia total o parcial en el aporte de oxígeno a los tejidos, además de que tenemos bases anatómicas y fisiológicas para limitar el bloqueo a los ganglios T2 y T3, considerados como las estaciones sinápticas que interrumpen los impulsos que se distribuyen en el miembro superior, siendo por tanto más selectivos y con menores efectos adversos para el paciente.

We present the results obtained in the validation of an analytical method, performed by high resolution liquid chromatography for the determination of ivabradine in tablets, which was designed to identify and quantify this analyte using an RP18 (150 x 4.6 mm) 5 mm column and a UV-Vis detector at λ: 285 nm. This method will be used to control the quality and stability of ivabradine tablets. The method was validated using a work methodology that followed the guidelines of The International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use, Validation of Analytical Procedures (ICH Q2). The following results were obtained: linearity (r2 = 0.999), precision Relative Standard Deviation (RSD) = 0.67 for pilot lot tablets and RSD = 0.31% for commercial lot tablets and accuracy, mean recovery = 100.2% thus demonstrating that the proposed method is applicable to the dosage of ivabradine in tablet form, both in the finished product analysis as in the stability studies.

RESUMEN

Purpose: The validation in critical patients with short-term catheters of a method for diagnosing catheter-related bloodstream infection (CR-BSI), based on the differential time to positivity (DTP) of blood cultures. Methods: Patients suspected of having CR-BSI were included. Two peripheral vein blood cultures and a catheter hub blood culture were simultaneously carried out. The responsible catheter was removed and tip cultured. Times to positivity of all blood cultures were automatically registered. CR-BSI was diagnosed when all the cultures were positive for the same microorganism and DTP>120min. This diagnosis was compared with the one obtained using the standard method. Results: 226 cases suspected of CR-BSI were analyzed during a 20-month period. A total of 19 removed catheters were associated with CR-BSI. Seven cases of polymicrobial cultures (4 with CR-BSI) were discarded from the final analysis due to the impossibility of determining the time to positivity for each individual microorganism. Using the DTP method, 12 out of 15 CR-BSI cases were diagnosed (sensitivity 80%, specificity 99%, PPV 92%, NPV 98%). In a ROC curve, we found a cut-off value of 17.7h in positivity of hub blood cultures that may be useful for diagnosing CR-BSI. Conclusion: DTP can be a valid method for CR-BSI diagnosis in critically ill patients, avoiding unnecessary catheter withdrawal.

Objetivos: La validación, en pacientes críticos con catéteres de corta duración, de un método diagnostico de la bacteriemia asociada a catéter (BAC) basado en la diferencia en el tiempo de positivización (DTP) de hemocultivos. Material y Métodos: Se incluyeron pacientes con sospecha de BAC en los que se realizaron 2 hemocultivos de sangre periférica y un hemocultivo a través de la luz distal del catéter sospechoso, antes de la retirada y cultivo de la punta del mismo. Se registraron automáticamente los tiempos de positivización de todos los hemocultivos. Diagnosticamos BAC cuando todos los hemocultivos fueron positivos para el mismo microorganismo y el DTP >120 minutos. La exactitud de este método diagnóstico fue comparada con la obtenida mediante el método estandar. Resultados: Se analizaron 226 casos de sospecha de BAC durante 20 meses. En 19 de ellos se diagnosticó BAC mediante el método estandar. En 7 casos los hemocultivos fueron polimicrobianos (4 de ellos asociados a BAC) por lo que tuvieron que ser descartados para el analisis final dada la imposibilidad de determiner el tiempo de positivización de cada microorganismo por separado. Siguiendo el método basado en el DTP, 12 de los 15 casos de BAC fueron diagnosticados correctamente (sensibilidad 80%, especificidad 99%, VPP 92%, VPN 98%). En una curva ROC, encontramos un punto de corte de 17.7 horas en el tiempo de positivización del hemocultivo a través de catéter que puede ser útil para el diagnóstico de BAC. Conclusion: La DTP puede ser un método valido para el diagnostico de BAC monobacteriana en pacientes críticos con catéteres de corta duración, evitando la retirada innecesaria de catéteres.